Highly Accelerated 3d Dynamic Contrast Enhanced Mri Using Partial Separability Model and Jsense

PURPOSE: Dynamic contrast enhanced (DCE) MRI requires high spatial resolution for morphological information and high temporal resolution for contrast pharmacokinetic modeling. The current fast imaging techniques [1-5] have shown success in improving the temporal resolution of DCE-MRI. However, it is still challenging to improve both the spatial and temporal resolutions simultaneously. This abstract presents a new approach to highly accelerated dynamic contrast enhanced MRI. Using a phased array coil, data was acquired continuously along a stack of variable-density spiral trajectories updated with the golden angle [6]. In reconstruction, the approach integrates parallel imaging [7,8] with the partial separable (PS) model [5,9,10] to obtain the image from highly undersampled data. The proposed method is evaluated on a set of in vivo dynamic contrast enhanced liver imaging data with prospective undersampling. The experimental results show that the proposed method is able to achieve high spatial and temporal resolutions at the same time.